Gun violence is a leading cause of death and a major cause of Black/White disparities in premature mortality among men. There is widespread pessimism about our ability to reduce gun violence in America, yet research indicates that the right policies, law enforcement practices, and behavioral interventions can reduce violence and save lives. Cultural divides over guns, policing practices, and race pose serious challenges, but are not insurmountable for us to forge more effective and just strategies to curb gun violence.